Friday, March 03, 2006

Making a Cell Part 2


Adeninine related nucleotides including ATP, and NAD(P), shown here, are important coupling compounds in metabolism


One of the important roles of Fueling reactions is to generate chemical energy for cellular activities.

This energy is in the form of either ATP or PMF.

Energy sources ATP and PMF are intra convertible by cells.

This energy can be used for either Growth related activities or Growth independent activities.

Another major fueling reaction is production of reducing power (carried by NAD(P) as Hydrogen atoms attached the nicotinamide ring) which is also consumed in growth-related processes.


Study questions:

What are examples of non-growth related processes that consume energy?


Quantitatively speaking:

What are the main growth related processes that consume ATP?

What are the main growth related processes that consume reducing power?

7 Comments:

Blogger Archeak9 said...

What are examples of non-growth related processes that consume energy?
Sensing, secretion (combined as communication) , taxis, , maintenance of pH, turgor & metabolite concentrations, repair of cellular structures and protein turnover.

Quantitatively speaking:
What are the main growth related processes that consume ATP?
Synthesis & polymerization of Amino acids via mRNA to give proteins. 72%
Synthesis & polymerization of NTPs to give tRNA & rRNA, 17%

What are the main growth related processes that consume reducing power?
Synthesis & polymerisation of Aminoacids via mRNA to give proteins. 63%
Synthesis of Phospholipids 30%

March 09, 2006 12:16 pm  
Blogger Microbe Pundit said...

Polymerisation of amino acids DOES NOT use reducing power, but the rest is very correct.

March 09, 2006 3:59 pm  
Anonymous fam said...

I think is the synthesis of building blocks (ie. amino acids) consume reducing power rather then polymerization of it.

March 09, 2006 10:44 pm  
Blogger Microbe Pundit said...

Yes, Fan thats the point of the question.

Next question: what parts of amino acids are reduced: which amino acids are more reduced and where are these reduced regions in proteins?

March 10, 2006 10:22 am  
Anonymous fam said...

The side chain of amino acid highly reduced. Phenoalanine, valine are amino acids that are more reduced.

March 10, 2006 10:35 pm  
Blogger Microbe Pundit said...

Good work Fam. The hydrophobic residues that you mention are an important driving force in formation of globular protein stucture. The reside within the interior of the globular protein. They are also important for proteins that reside in membranes. As these globular proteins carry out crucial biological functions like enzyme catalysis and regulation circuits, reduction of amino acid side chains is an import process.

Thats why I asked the question.
Discussion thread ended for me.

March 12, 2006 3:45 pm  
Blogger karthiben said...

brilliant. learning lots on bioprocess engineering. definitely a good resource for students of the course.

good luck everyone for the exam tomorrow!

June 05, 2007 7:27 pm  

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